Vol. 2025 No. HVBTE (2025): Proceedings of the The 10th Heart Valve Biology and Tissue Engineering Meeting

Epidemiology of Heart Valve Disease

KEYNOTE: The impact of heart valve disease on patient lives, economy and society: a global perspective

Hanneke Takkenberg
Mitral Valve Prolapse and Arrhythmic Sudden Death

Gaetano Thiene
Rationale and Need for Cardio-Obstetric Care Units

Susy Kotit, Nagwa Ibrahim, Soha Heikal, Magdi Yacoub
The epidemiology of degenerative mitral valve disease: Chicken and egg, the old conundrum

Francis Wells

Developmental Biology of Heart Valves

KEYNOTE: Hemodynamic disruption in the proximal outflow tract generates complex congenital heart valve defects without genetic mutation

Jonathan Butcher
The AV Conduction System in Bicuspid Aortic Valve (BAV)

Gaetano Thiene, Chiara Fraccaro
Generation of Valvular Interstitial Cells from Human Pluripotent Stem Cells

Amine Mazine
Spatial Variations in Shear Stress Activate klf2a-snai1b Signaling for Bicuspid to Multicuspid Valve Formation

Jing Wang, Aaron L Brown, Charlie Z Zheng, Alexander D Kaiser, Tomohiro Yokota, Seul-Ki Park, Alison L Marsden, Tzung K Hsiai

Matrix Biology Relevant to Heart Valves

KEYNOTE: Heart Valve Glycomechanobiology

Jane Grande-Allen
Bio-Hybrid Cardiac Patches with Sustained Losartan Delivery: A Strategy Against Left Ventricular Remodeling

Melika Malekhosseini
A Computational Fluid Dynamics (CFD) analysis to optimize size and shape pattern for endothelial cell growth

Enrica Romano, Nunzio Cancilla, Frederica Cosentino, Marta Baccarella, Michele Ciofalo, William Richard Wagner, Giorgio Domenico Maria Micale, Alessandro Tamburini, Antonio D'Amore

Mechanobiology

Comparative Analysis of the Endothelial Glycocalyx in Aortic Valve and Vascular Endothelial Cells Under Distinct Shear Stress Conditions

Eze Ezeokeke, Jospeh Stroschein, Anael Roig-Gicquel, Siddharth Prakash, Jane Grande-Allen
Mechanically Activated snai1b Coordinates the Initiation of Myocardial Delamination for Trabeculation

Jing Wang, Aaron L Brown, Seul-Ki Park, Charlie Z Zheng, Adam Langenbacher, Enbo Zhu, Ryan O'Donnell, Peng Zhao, Jeffrey Hsu, Jiandong Liu, Jau-Nian Chen, Tomohiro Yokota, Alison L Marsden, Tzung K Hsiai
Studying Cardiovascular Mechanobiology in Development and Disease with Zebrafish

Huseyin C. Yalcin
Cell-type Specific GTPase Regulation of Aortic Valve Homeostasis and CAVD Progression

Janani Guru, Kenny Nguyen, Katherine Driscoll, Jonathan Butcher

Molecular Mechanisms of Heart Valve Disease

KEYNOTE: Mechanisms of Calcific Aortic Valve Disease Visualized Through the Lens of Multi-Omics

Elena Aikawa
Asymmetric Cellular and Structural Contributions to Cusp-Specific Remodeling and Malformation in the Aortic Valve

Daniel Chaparro, Joshua Hutcheson
δ-granules from thrombocytes and the origin of the early calcified structures of cardiovascular calcification

Sergio Bertazzo, Elena Tsolaki, Shweta Agarwal, Ken Smith, Janice Tsui, Najma Latif, Adrian Chester

Innovation in Valve Repair and Replacement

KEYNOTE: Innovation in pediatric heart valve repair and replacement

Pedro J. del Nido
KEYNOTE: In vivo remodeling of mitral valve leaflet following transcatheter edge-to-edge repair in humans

Micheal S. Sacks
Transcatheter Edge-to-Edge Repair for Tricuspid Regurgitation – Initial Experience from an Irish Centre

Suleiman Obeidat, Conor Doyle, James Carey, Ellen Beirne, Susi Gnanaraj, Jamie Byrne, Niamh Mattimoe, Roger Byrne, Laura Murphy, Diarmaid Cadogan, Lavanya Saiva, Martin Lenihan, Andrew Sharp, Ronan Margey, Mark Spence, Ivan Casserly
Partial heart transplantation using ice-free cryopreservation – Homovitals 2.0

Ulrich Stock, Kelvin Brockbank, Taufiek Konrad Rajab
Effects of Surgical Replacement Aortic Root Geometry on Aortic Valve Function using Fluid-Structure Interaction Simulations

Hussam El-Nashar, Daniel Watson, Deniz Deniz Ozturk, Malak Sabry, Nairouz Shehata, Amr El-Sawy, Mohamed Nagy, Yuan-Tsan Tseng, Yasmine Aguib, Magdi Yacoub, James Moore Jr.

Preclinical Testing of Heart Valves

Application of a Staged Validation Approach to Patient-Specific Tissue Restoration Pulmonary Heart Valve FSI Simulations: From Material Testing to Post-Op and Long Term Modeling

Deniz Ozturk, Maria Bastron, Fabrizio Crasci, Salvatore Pasta, Tahir Turgut, Nils Götzen, Martijn Cox, Mikel Isasi, Malte Rolf-Pissarczyk, Maximilian Peter Wollner, Bart Meuris, Nele Famaey
StressMAP: A Surrogate Model for Predicting Pacemaker Dependency in TAVI In-Silico Trials

Yidan Xue, Ali Sarrami-Foroushani, Haoran Dou, Alejandro F. Frangi
A Novel 3D Segmentation Technique for Patient-Specific Aortic Valve Modeling

Mohamed Nagy, Magdi H. Yacoub
Standardised Framework for Preclinical Translation of Paediatric Heart Valve Technologies

Eleni Anna Kostopoulou, Fergal J O'Brien, Claire M Brougham

Heart Valve Tissue Engineering

KEYNOTE: Understanding material-driven in-situ heart valve tissue regeneration

Carlijn Bouten
Clinical Vascular Tissue Engineering Under GMP Conditions

Johann Meinhart, Petros Skyllouriotis, Norbert Howanietz, Ivan Matia, Karin Schmidt, Heinz Schulz, Ingo Crailsheim, David Misoga, Michael Gorlitzer, Andreas Stuempflen, Martin Grabenwoeger, Peter Zilla
Synchrotron X-Ray Computational Tomography of Fibrous Scaffolds for Morphological Characterisation

Yuan-Tsan Tseng, Rudolf Hellmuth, Marathe Shashidhara, Yunpeng Jia, Oriol Roche, Josh Williams, Kaz Wanelik, Marco Endrizzi, Magdi Yacoub
A Bioinspired Mitral Valve: Integrating Melt-electrowritten Scaffolds with a Human Placenta-derived Extracellular Matrix Hydrogel

Kilian Mueller, Severin Riedlhammer, Matthias Pixner, Michael Pressnig, Paula Castejón Echevarne, Karl Schneider, Petra Mela
Lab Grown Bioengineered Tissue-based Valved Conduit with Somatic Growth Potential and Framed Valve for Congenital Pulmonary Valve Disease

Zeeshan Syedain, Mariah McMahon, Abrielle Prunty, Jakob Benkofske, Mathew Lahti, James Berry, Richard Bianco, Gurumurthy Hiremath, Robert Tranquillo
Characterization of resolvable polymers used for developing in utero fetal valve replacements

Sanchita Bhat, Julia Toma, Aimee Armstrong, Christopher Breuer, Lakshmi Prasad Dasi
Spatiotemporal Assessment of (Patho)physiological Tissue Remodeling and Mechanics in In Situ Tissue-Engineered Pulmonary Valves in Sheep

Sofia Artamonova, Elmer Middendorp, Silvia Dekker, Katja Schenke-Layland, Elena Aikawa, Carlijn Bouten, Sandra Loerakker, Anthal Smits

The Ross Operation

North American Trends in Utilization and Outcomes of the Ross Procedure: A Word of Caution

Amine Mazine, Steve Fan, Joanna Chikwe, Nimesh Desai, Jennifer Chung, Jad Malas, Kevin Chen, Angel Chen, Kyle Runeckles, Michael Bowdish, Joseph Bavaria, Marai Ouzounian
Biofilm-Forming ST-45 Staphylococcus aureus Causing Late Pulmonary Homograft Endocarditis Post-Ross Procedure

Emmanouela Chourda, Giovanni Melina, Stefania Stefani, Fabio Miraldi, Magdi Yacoub
Endocarditis following the Ross procedure: the advantage of a living valve

Giuditta Coppola, Giovanni Melina, Fabio De Robertis, Maximiliaan Notenboom, Mohammad Yousuf Bilal Salmasi, Paolo De Siena, Mohamed Elshalkamy, Shiva Seyed Mokhtassi, Albaraa Al Holy, Mario Petrou, Julien Gaer, Ismail El-Hamamsy, Joanna J.M. Takkenberg, Magdi Yacoub

Rheumatic Heart Disease

KEYNOTE: Complement and immunoglobulin genes in rheumatic heart disease

Tom Parks
Progressive deterioration in clinical outcome in RHD: influence of therapeutic interventions

Susy Kotit, Shehab Anwer, Magdi Yacoub
Lessons Learned, Foundation Laid - Time For The Clinical Leap

Peter Zilla
Structural Remodeling in Rheumatic Heart Disease: Influence of Age and Gender in an Egyptian Cohort

Mohamed Roshdy, Ayman M. Ibrahim, Arwa Kohela, Susy Kotit, Mina Azer, Eslam Soror, Eslam Abdelaziz, Sarah Halawa, Najma Latif, Hatem Hosny, Ahmed Afifi, Yasmine Aguib, Magdi Yacoub
Expression of Toll-Like Receptor-2 and -4 in Normal Human Valves and Dysregulated Expression in Valves from Rheumatic Heart Disease Patients

Najma Latif, Padmini Sarathchandra, Ann McCormack, Magdi Yacoub

Keynote Presentations

Biologically-engineered pediatric conduits that grow

Robert Tranquillo

Poster Presentations

Toward a Bioinspired Tissue Engineered Mitral Valve: In Silico Optimization of the Chordal Apparatus in a Polymeric Mitral Valve

Elisa Lanzalaco, Joan Dario Soto Laubrie, Frederica Cosentino, Giuseppe Raffa, Michele Pilato, Vincenzo La Carrubba, Antonio Pantano, Antonio D'Amore
Effect of hyperglycaemia and the antidiabetic drug “metformin" on heart valve endothelial cells

Isra Marei, Omar Khalil, Arwa Saed Aldien, Ahmed Aly, Khalifa Bshesh, Haissam Abou Saleh, Hong Ding, Adrian Chester, Chris Triggle
Characterizing transmural ingrowth spaces: a key step towards clinical in-situ endothelialization

Andrea Tonelli, Francesco Iacoviello, Stephen Kelly, Dirk Lang, Jaco Theron, Timothy Pennel, Peter Zilla
The Role of Valve Endothelial Cells in Aortic Valve Calcification

Daria Evensen, Arsenii Zabirnyk, Krizia Sagini, Hanne Haslene-Hox, Alicia Llorente Martinez, Mari-Liis Kaljusto, John-Peder Escobar Kvitting, Kåre-Olav Stensløkken, Jarle Vaage
Effect of Inorganic Body Mimetic Solutions and Chemical Modifications on the Calcium Phosphate Precipitation on Pericardium used in Bioprosthetic Heart Valves

Ffion Parry, Elisa Barrere, Evelina Obretetskaya, Vicky Julius Mawuntu, Sergio Bertazzo
Understanding the Functional Role of Shear- and Side-dependent MicroRNA-214 in Aortic Valve Biology

Swetha Rathan, Sivakkumar Arjunon, Sandeep Kumar, Joan Fernandez Esmerats, Jack heath, Md. Tausif Salim, Robert Nerem, Ajit Yoganathan, Hanjoong Jo
Aberrant Regulation of endMT in Turner Syndrome: Implications for the Pathogenesis of Congenital Cardiovascular Disease

Eric Ivan Garcia Huitron, Xiaoying Zhang, Lance Babcock, Jane Grande-Allen, Siddharth Prakash
Engineering Functional Chordae Tendineae: A Mandrel-Less Biofabrication Approach For Heart Valve Repair

Flaviana Falci, Arianna Adamo, Ignazio Niosi, Pietro Terranova, Valeria Vetri, Antonio D'Amore
Engineering Living Tissues Clinical Translation: From Dialysis Access Conduit to Congenital Heart Valves

Zeeshan Syedain
Elucidating the mechanosensitive pathways of physiological and pathological strain on valve cells in a novel human valve-on-chip system

Gustavo Vaca-Diez, Connor Robinson, Kartik Balachandran
Finite Element Analysis of Self Expanding Transcatheter Aortic Valves reveals Increased Stent contact Pressure is Associated with Higher Conduction Abnormality Risk

Huseyin C. Yalcin, Onur Mutlu, Noaman Mazhar, Himanshu Lajpat, Abdulrahman Al-Nabti
Mapping the Proteomic Landscape of Congenital Aortic Valve Stenosis Using a Notch1;Gata5 Mutant Mouse Model

Anupama Rao, Talita Choudhury, Airines Valezquez, Sean Angler, Sarah Greskovich, Vidu Garg
Purinergic Ecto-Enzymes in Human and Ovine Aortic Valves: Indicators of Bacterial Nanocellulose Scaffold Cellularization

Barbara Kutryb-Zajac, Ada Kawecka, Gabriela Harasim, Michal Bienkowski, Klaudia Stawarska, Ryszard T. Smolenski, Maciej Kowalik, Magdalena Kolaczkowska, Piotr Siondalski
Image Processing Workflow for Characterising X-Ray Computational Tomography of Polymeric Scaffolds with Cells

Josh Williams, Rudolf Hellmuth, Yuan-Tsang Tseng, Marta Peña Fernández, Oriol Roche i Morgo, Yunpeng Jia, Marco Endrizzi, Kazimir Wenelik, Leonard Turpin, Shashidhara Marathe, Magdi Yacoub
The Critical Role of Presettable and Expandable Artificial Surgical Valves in the Lifetime Management of Valvular Heart Disease

Kangjian Wu, Jia Wu, Tongtong Wu, Can Jin, Kevin Chen, Lei Jin
Structural and Biochemical Characterisation of Endothelialization of Aortic Valve Bacterial Nanocellulose (BNC) Bio-Prosthesis in an Ovine Model

Barbara Kutryb-Zajac, Gabriela Harasim, Ada Kawecka, Michal Bienkowski, Klaudia Stawarska, Krzysztof Urbanowicz, Ryszard T. Smolenski, Maciej Kowalik, Magdalena Kolaczkowska, Piotr Siondalski
FSI Modeling of the Sapien 3 Ultra Valve: Development, Verification, and Validation per ASME V&V 40

Deniz Ozturk, Maria Bastron
Investigation of subaortic membrane pathology by means of in vitro and in silico analysis

Alessandra Monteleone, Sofia Di Leonardo, Danila Vella, Calogera Pisano, Vincenzo Argano, Gaetano Burriesci
Transcatheter Edge-to-Edge Repair for Mitral Regurgitation – Real World Experience from an Irish Centre

Suleiman Obeidat, Conor Doyle, James Carey, Ellen Beirne, Susi Gnanaraj, Jamie Byrne, Niamh Mattimoe, Roger Byrne, Laura Murphy, Diarmaid Cadogan, Lavanya Saiva, Martin Lenihan, Andrew Sharp, Ronan Margey, Mark Spence, Ivan Casserly
The Methylation Landscape Of Human Aortic And Mitral Valvular Interstitial Cells

Sarah Halawa, Najma Latif, Yuan-Tsan Tseng, Adrian H Chester, Ahmed Moustafa, Yasmine Aguib, Magdi Yacoub
Navigating coronary anomalies: myocardial protection during cardiac surgery with a single coronary ostium

Harry Smith, Ujjawal Kumar, Urszula Simoniuk, Espeed Khoshbin
Persistent Immunopathological Activity in Excised Valves from Rheumatic Heart Disease Patients in an Egyptian Cohort

Mohamed Roshdy, Arwa Kohela, Ayman M. Ibrahim, Susy Kotit, Mina Azer, Eslam Soror, Eslam Abdelaziz, Sarah Halawa, Najma Latif, Hatem Hosny, Ahmed Afifi, Yasmine Aguib, Magdi Yacoub
Influence of Mechanical Environment on Aortic Valve Calcification, Thickening, Osteogenic marker Expression and ECM composition: Findings from an Ex Vivo Model

M. El Ouraoui, H.W. Wu, J.W. Jukema, N. Ajmone Marsan, B.P.T. Kruithof
Meso-Scale Topological Cues To Promote Endothelial Cell Proliferation On Macro-Scale, Blood-Contacting Polymeric Substrates

Marta Baccarella, Federica Cosentino, Pietro Terranova, Enrica Romano, Vincenzo La Carrubba, Francesco Lopresti, Claudio Arnone, William W. Wagner, Abdul I. Barakat, Alessia Castagnino, Antonio D'Amore
Regional Failure Properties of Ex-Vivo Ascending Thoracic Aortic Aneurysms

William Zhu, Axel Gomez, William Carroway, Yixuan Huang, Camille Neal-Harris, Marko Boskovski, Liang Ge, Elaine Tseng
Establishing Warfarin Clinics for improved Anticoagulation Management in Ethiopia

Susy Kotit, Lisa Yacoub, Eliezer Bekele, Shehab Anwer, Miklol Mengistu, Samson Addera, David I.W. Phillips, Magdi Yacoub
Sexually Dimorphic Effect of Shear Stress Using Porcine Aortic Valve Endothelial Cells

Eric Ivan Garcia Huitron, Tori Barrera, Erin Stout
Activated platelets are molecular drivers of endothelial-to-mesenchymal transition in calcific aortic valve disease

Luisa Weiss, Taku Kasai, Sasha Singh, Masanori Aikawa, Elena Aikawa
Establishing a Rheumatic Heart Disease Registry in Ethiopia Based on the ARGI

Susy Kotit, Lisa Yacoub, Eliezer Bekele, Shehab Anwer, Miklol Mengistu, Samson Adera, David I.W. Phillips, Magdi Yacoub
Bicuspid Aortic Valve: a not so Benign Congenital Heart Disease

Gaetano Thiene, Chiara Fraccaro
The Cairo Accord: Towards the eradication of RHD - an update (2025)

Susy Kotit, David I.W. Phillips, Magdi Yacoub
Patient-Specific Fluid–Structure Interaction Modeling of the Sapien 3 Ultra Valve with Clinical Validation in a Small Patient Cohort

Deniz Ozturk, Maria Bastron
Bioprocessing and in-vitro assessment of a biomimetic polymeric mitral valve

Ignazio Niosi, Viktor Balashov, Pietro Terranova, Matthias Jacquot, Adriano Adamo, Flaviana Falci, Patrizia Caruso, Antonio Pantano, William Wagner, Antonio D'Amore

Vol. 2025 No. HVBTE (2025): Proceedings of the The 10th Heart Valve Biology and Tissue Engineering Meeting

Epidemiology of Heart Valve Disease

Developmental Biology of Heart Valves

Matrix Biology Relevant to Heart Valves

Mechanobiology

Molecular Mechanisms of Heart Valve Disease

Innovation in Valve Repair and Replacement

Preclinical Testing of Heart Valves

Heart Valve Tissue Engineering

The Ross Operation

Rheumatic Heart Disease

Keynote Presentations

Poster Presentations

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